The 83-year-old California Democrat announced her plans on Friday.
Pelosi is the longest-serving female Speaker of the House in history.
"I am running for reelection because our country needs America to show the world that our flag is still there, with liberty and justice for all," she said.
Will Pelosi be able to win reelection at age 83?
It remains to be seen, but she is a formidable campaigner and has a strong base of support in her district.
Pelosi's announcement helps Dems' chances in '24 House race
We need to elect a Democratic Congress that will fight for working families," she said.
Who are Pelosi's potential challengers?
There are no declared challengers yet, but some Democrats have expressed concerns about her age and leadership style
Pelosi has been a controversial figure throughout her career, but she is also a respected leader.
"She is a force of nature," said one Democratic strategist.
How will Pelosi's reelection affect the 2024 elections?
It remains to be seen, but her presence could be a deciding factor in the race for the House.